Publication 1: Gram Scale Synthesis of Azetidinium Salts in Flow

Vile and co-workers have reported a practical procedure for the on-demand preparation of synthetically useful azetidinium salts via aminolysis of epichlorohydrin under continuous flow conditions. Using the Uniqsis FlowLab flow chemistry reactor system, the procedure is both simple and scalable affording high yields of products that can be isolated directly within 60 minutes at 80oC. Typically higher yields are obtained in flow than in the corresponding batch process.

了解详情 >>

Publication 2: Continuous Flow Synthesis of Indoles by Pd-Mediated Reduction of o-Nitrostilbenes with Carbon Monoxide

The Pd-mediated reduction of o-nitrostilbenes in the presence of carbon monoxide is reported to proceed regioselectively under pressurised flow-through conditions to cleanly afford indoles. A variety of substrates are tolerated and the reaction proceeds significantly faster than in batch and produces carbon dioxide as the only stoichiometric side-product.

了解详情 >>

平推流化学（Plug Flow Chemistry）

平推流是流动反应器的关键特性，指初始时刻进入反应器的任意两个分子，将在相近时间内流出反应器。平推流反应器（PFR）模型为反应时间控制提供了有效手段，同时可优化反应物与产物的分离效果。除少数特殊应用场景外，良好的平推流状态是保障反应器高性能的核心 —— 其意味着流体以时间有序的方式通过反应器，且无返混现象。采用平推流化学技术的反应器通常称为平推流反应器（PFR）。

了解详情 >>